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Gene expression Investigation exposed that ACKR3 is highly expressed in many brain areas corresponding to critical opioid activity facilities. Additionally, its expression amounts are sometimes greater than those of classical opioid receptors, which further supports the physiological relevance of its noticed in vitro opioid peptide scavenging capab
These final results, together with a prior report exhibiting that a small-molecule ACKR3 agonist CCX771 displays anxiolytic-like conduct in mice,2 assist the notion of focusing on ACKR3 as a singular approach to modulate the opioid technique, which could open new therapeutic avenues for opioid-associated disorders.Morphine as well as other opioids